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Hyaluronic Acid In Animal Tissues

Qufu Focuschem Trading Co.,Ltd | Updated: Oct 09, 2016

    The extraction from animal tissues, to be applied at industrial scale, was the extraction of hyaluronan from animal waste which is still an important technology for commercial products, but is hampered by several technical limitations. One drawback in the extraction process is the inevitable degradation of hyaluronan, caused by (a) the endogenous hyaluronidase activity in animal tissues, breaking down the polymer chain through enzymatic hydrolysis, and (b) the harsh conditions of extraction. Extraction protocols have been improved over the years, but still suffer from low yields, due to the intrinsic low concentration of hyaluronan in the tissue, and from high polydispersity of polymer products due to both the natural polydispersity of hyaluronan and to the uncontrolled degradation during extraction. As in any process for the production of therapeutic compounds from animal sources, there is a potential risk of contamination with proteins and viruses, but this can be minimized by using tissues from healthy animals and extensive purification. Nevertheless, concerns on viral (particularly avian) and protein (particularly bovine) contamination increased the interest in the biotechnological production of hyaluronan.