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Physicochemical Properties Of Chondroitin Sulfate

Qufu Focuschem Trading Co.,Ltd | Updated: Jun 14, 2017

     Chondroitin sulfate (CS) is a class of glycosaminoglycans that are covalently attached to proteins to form proteoglycans. Chondroitin sulfate is widely distributed in the extracellular matrix and cell surface of animal tissues. The sugar chain consists of alternating glucuronic acid and N-acetylgalactosamine (also known as N-acetylgalactosamine) disaccharide units, The link region is attached to the serine residue of the core protein.Chondroitin Sulfate  Chondroitin sulfate is present in all organisms from nematodes to humans except plants and plays a number of important physiological functions. Although the main chain structure of the polysaccharide is not complicated, there is a high degree of heterogeneity in terms of the degree of sulfation, the sulfuric acid group and the distribution of the two differences to the isomerized uronic acid. The fine structure of chondroitin sulfate determines the specificity of the function and the interaction with a variety of protein molecules.Chondroitin Sulfate In 1956, Meyer et al first began to study the types and contents of acidic mucopolysaccharides in different tissues, and identified mucopolysaccharides such as CS and hyaluronic acid and keratan sulfate in connective tissue. CS in acid, alkaline and enzymatic conditions generated under the unsaturated sugar, including low molecular weight CS and CS oligosaccharides or disaccharides are related to β-elimination reaction. The degree of degradation of CS in acidic, alkaline and neutral conditions is expressed as the UV absorbance at 232 nm. The larger the UV absorbance value is, the greater the degree of degradation, which reflects the stability of CS under different conditions. CS is extracted from the animal tissue prepared acidic mucopolysaccharide, white or almost white powder; odorless; with wetting. The aqueous solution of this product is viscous and does not heat up. This product is soluble in water, insoluble in ethanol, acetone, and ether and other organic solvents, the salt is relatively stable heat, heat up to 80 ℃ is not destroyed. Chondroitin sulfate aqueous solution, the case of high temperature or acid that is unstable, mainly deacetyl or degradation into monosaccharides or less molecular weight polysaccharide.Chondroitin Sulfate